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Aerpio offers update on Aadi Bioscience Presentation on the ASCO 2021 virtual assembly

CINCINNATI, may additionally 19, 2021 (GLOBE NEWSWIRE) -- Aerpio pharmaceuticals, Inc. (“Aerpio”) (Nasdaq: ARPO) announced that Aadi Bioscience (“Aadi”), a privately-held biopharmaceutical business focusing on precision remedies for genetically-described cancers with ameliorations in mTOR pathway genes, these days issued an announcement disclosing its summary to be offered on the American Society of clinical Oncology (ASCO) 2021 Annual assembly. As previously disclosed, on might also 16, 2021, Aerpio entered into an agreement and Plan of Merger among Aerpio, Aadi, and Aspen Merger Subsidiary, Inc. About Aerpio prescribed drugs Aerpio pharmaceuticals, Inc. is a biopharmaceutical company focused on establishing compounds that prompt Tie2 for signals wherein the company believes that activation of Tie2 might also have therapeutic capabilities. For extra information, please visit www.aerpio.com. About Aadi Bioscience Aadi is a medical stage biopharmaceutical enterprise constructing precision healing procedures for genetically-described cancers. Aadi’s basic intention is to bring transformational outcomes to cancer patients with mTOR pathway driver variations the place other mTOR inhibitors have not or can not be simply exploited because of complications of pharmacology, positive drug start, safeguard, or constructive targeting to the disorder site. Aadi’s product FYARROTM (sirolimus albumin-certain nanoparticles for injectable suspension; nab-sirolimus; ABI-009) is an mTOR inhibitor sure to human albumin that has confirmed significantly higher tumor accumulation, mTOR goal suppression, and advanced efficacy over other mTOR inhibitors in preclinical models.1 Aadi’s preliminary focus is on treating sufferers with changes in TSC1 or TSC2 genes, tumor suppressors that after inactivated, may be drivers in numerous melanoma varieties. Aadi’s registration trial in advanced malignant PEComa (the AMPECT trial) of FYARRO tested meaningful medical efficacy in malignant PEComa2, a type of melanoma with the optimum usual mutation cost of TSC1 or TSC2 genes. in response to the AMPECT trial, rising statistics for FYARRO in other strong tumors with TSC1 or TSC2 mutations, and following discussions with the FDA, Aadi plans to initiate a tumor-agnostic registrational trial in cancers harboring TSC1 or TSC2 inactivating adjustments by the end of 2021. Aadi additionally has ongoing experiences to consider dosing of FYARRO in aggregate regimens. extra information is purchasable on the Aadi site at www.aadibio.com. No present or Solicitation This verbal exchange isn't supposed to and shall not constitute a proposal to purchase or sell or the solicitation of a suggestion to buy or sell any securities, or a solicitation of any vote or approval, nor shall there be any sale of securities in any jurisdiction during which such offer, solicitation or sale would be illegal prior to registration or qualification below the securities legal guidelines of any such jurisdiction. No providing of securities might be made, except through capacity of a prospectus meeting the requirements of area 10 of the U.S. Securities Act of 1933, as amended. additional info in regards to the Proposed Transaction for investors and Shareholders This communique relates to the proposed transaction involving Aerpio and Aadi and can be deemed to be solicitation cloth in recognize of the proposed transaction. In reference to the proposed transaction between Aerpio and Aadi, Aerpio will file a proxy commentary with the Securities and alternate fee (“SEC”). This conversation is not an alternative to the proxy statement or any other documents that Aerpio may additionally file with the SEC or ship to Aerpio shareholders in connection with the proposed transaction. earlier than making any balloting choice, buyers and security holders are entreated to examine the proxy remark and all other valuable files filed or that might be filed with the SEC in connection with the proposed transaction as they develop into available because they'll contain critical tips in regards to the proposed transaction and linked concerns. investors and safety holders may additionally obtain free copies of the proxy commentary and all different files filed or that might be filed with the SEC concerning the proposed transaction on the website maintained through the SEC www.sec.gov. as soon as filed, the proxy commentary should be obtainable free of can charge on Aerpio’s web site at www.aerpio.com or by using contacting Aerpio’s vice president of Finance by means of electronic mail at gmarek@aerpio.com. participants within the Solicitation Aerpio, Aadi and their respective administrators and executive officers may well be deemed to be participants within the solicitation of proxies from the stockholders of Aerpio in reference to the proposed transaction. assistance about Aerpio’s administrators and government officers is set forth in Aerpio’s Annual record on form 10-ok for the yr ended December 31, 2020, which changed into filed with the SEC on March eleven, 2021, and in subsequent filings made by Aerpio with the SEC. other information regarding the pursuits of such individuals, as well as information related to Aadi’s directors and executive officers and different people who may be deemed members within the proposed transaction, could be set forth in the proxy commentary and different significant substances to be filed with the SEC once they develop into accessible. You may attain free copies of these files as described in the preceding paragraph. ahead searching Statements This conversation carries “ahead-looking statements” based upon Aerpio’s and Aadi’s latest expectations. ahead-searching statements involve dangers and uncertainties, and encompass, but aren't constrained to, statements concerning the structure, timing and completion of the proposed transaction; the mixed company’s listing on Nasdaq after the closing of the proposed transaction; the company of the combined company, together with Aadi’s product candidates, the building therefor and the therapeutic capabilities thereof; the proposed PIPE and its phrases; the use of proceeds from the proposed PIPE; Aerpio’s product candidates, including the possibility for Aerpio shareholders to acquire price from such assets during the proposed contingent cost rights. exact effects and the timing of pursuits can also fluctuate materially from those indicated with the aid of these forward-looking statements on account of quite a lot of critical components, including, with out quandary: (i) dangers linked to Aerpio’s capacity to achieve the stockholder approval required to consummate the proposed transaction or to comprehensive the PIPE financing, and the timing of the closing of the proposed transaction, together with the hazards that a situation to closing would now not be satisfied in the expected timeframe or in any respect or that the closing of the proposed transaction, including the PIPE financing, will no longer turn up (ii) the response of Aerpio’s stockholders to the proposed transaction; (iii) dangers regarding Aerpio’s skill to manipulate its working fees and its fees linked to the proposed transaction pending closing; (iv) risks regarding the failure or lengthen in acquiring required approvals from any governmental or quasi-governmental entity imperative to consummate the proposed transaction; (v) the risk that because of changes to the trade ratio, Aerpio stockholders and Aadi stockholders may own extra or less of the mixed company than is presently anticipated; (vi) dangers concerning the market price of Aerpio’s regular inventory relative to the alternate ratio; (vii) sudden costs, prices, costs or fees due to the proposed transaction; (viii) skills hostile reactions or alterations to business relationships resulting from the announcement or completion of the proposed transaction; (ix) Aerpio’s capacity to retain personnel because of the announcement or completion of the proposed transaction; and (x) risks associated with the possible failure to know certain expected benefits of the proposed transaction, together with with admire to future fiscal and operating effects and (xi) the possibility that any advantage charge of proceeds pursuant to the CVR contract might also not be distributed in any respect or outcomes in any value to Aerpio stockholders. genuine effects and the timing of hobbies can also differ materially from those expected in such ahead-searching statements because of these risks and uncertainties. These and other hazards and uncertainties are more totally described in periodic filings with the SEC, including the elements described in the part entitled “chance factors” in Aerpio’s Annual document on kind 10-okay for the yr ended December 31, 2020, which changed into filed with the SEC on March eleven, 2021 and in different filings that Aerpio makes and should make with the SEC in connection with the proposed transaction, including the Proxy commentary described above below “additional info concerning the Proposed Transaction and where to locate It.” be sure to no longer vicinity undue reliance on these forward-looking statements, which follow best as of the date of this verbal exchange. Aerpio expressly disclaims any obligation or engaging in to unencumber publicly any updates or revisions to any ahead-searching statements contained herein to reflect any exchange in its expectations with regard thereto or any exchange in events, conditions or circumstances on which this sort of statements are based. These forward-looking statements are made as of the date of this press release, and Aerpio assumes no obligation to update the forward-searching statements, or to replace the the reason why precise outcomes may vary from these projected in the forward-looking statements, except as required through law. traders may still consult all of the information set forth herein and should also seek advice from the possibility ingredient disclosure set forth within the reviews and other files Aerpio data with the SEC obtainable at www.sec.gov. References: 1 AACR 2019 summary: https://cancerres.aacrjournals.org/content/79/13_Supplement/348 2 ASCO 2020 summary: https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.11516?af=R Contacts investors & Media:Aerpio prescribed drugs, Inc. Gina MarekVP Financegmarek@aerpio.com Or investors:Irina KofflerLifeSci Advisorsikoffler@lifesciadvisors.com source: Aerpio pharmaceuticals, Inc.

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